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Music is often used as a nonpharmacological pain management strategy, but little evidence is available about its role in pediatric critical care patients. There are a few studies exploring the effects of recorded music with pediatric critical care patients but the results for recorded music are inconsistent. This oral paper will present results from an exploratory randomized controlled trial performed in a pediatric intensive care unit. Participants were randomly allocated to receive a live music therapy intervention with standard care or a recorded music intervention with standard care. Participants were pediatric patients who were intubated and sedated and received the randomized allocation for 15 minutes. Heart rate, respiratory rate, and blood pressure were recorded every fifteen minutes at seven time points. In the live music therapy group, a significant reduction in heart rate was observed immediately following the intervention and was sustained at 60 minutes after the intervention.